As Part of a Long-Term Cohort Study, Members of a Large

question 73

Multiple Choice

As part of a long-term cohort study, members of a large extended family undergo periodic analysis of multiple serum markers.  Many male participants are found to have abnormal laboratory results despite no obvious signs of disease.  Further analysis shows that these men have an X-linked mutation affecting the phosphoribosyl pyrophosphate (PRPP) synthetase gene, resulting in greatly increased substrate conversion.Which of the following organs is most likely to develop pathology secondary to this mutation?

• A)Aorta
• B)Heart
• C)Joints
• D)Liver
• E)Pancreas

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Definitions:

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Then

Used to indicate what happened or happens next in a sequence of events.

Who's

The contraction of "who is" or "who has."

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To be deprived of something or fail to win, such as losing an object, game, or opportunity.