A Group of Researchers Conduct a Study to Evaluate the Pharmacologic

question 19

Multiple Choice

A group of researchers conduct a study to evaluate the pharmacologic properties of oxfendazole, an anthelminthic agent.  As part of the study, increasing oral doses of oxfendazole (0.5 to 60 mg/kg) are administered to healthy volunteers.  Data is collected to form a pharmacokinetic profile of the drug and its metabolites, and the incidence of adverse effects is recorded for the various dosages.  A total of 20 healthy male and female (nonchildbearing potential) volunteers participate in the study.  Oxfendazole is found to be well tolerated throughout the dose range without any serious adverse effects or deaths.  Which of the following best describes this type of study?

• A)Preclinical study
• B)Phase I clinical trial
• C)Phase II clinical trial
• D)Phase III clinical trial
• E)Phase IV clinical trial

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Definitions:

Generalized Fisher Effect

The theory suggests that the real interest rate is independent of monetary measures, relating nominal interest rates in one country to expected inflation rates.

Triangle Arbitrage

A method of profiting from the inconsistency in exchange rates between three currencies in the foreign exchange market by converting them sequentially.

Canadian Dollar

The official currency of Canada, often represented by the symbol CAD or $CA, and used throughout the Canadian economy.

U.S. Dollar

The official currency of the United States, widely used as a benchmark and reserve currency around the world.