Carbamoyl Phosphate Synthetase I Deficiency Is an Inherited Disorder Characterized

question 13

Multiple Choice

Carbamoyl phosphate synthetase I deficiency is an inherited disorder characterized by accumulation of ammonia in the blood.  The most severe form occurs in the first 24-72 hours following birth, after feeding begins and milk proteins start to be broken down in the liver.  If left untreated, affected neonates often die due to severe metabolic derangements; survivors often develop permanent neurologic injury.  The estimated incidence of carbamoyl phosphate synthetase I deficiency is about 1 in 800,000 newborns.  If a decision is made to test all newborns for this disease, then this initial test should be designed to have a high:

• A)Cutoff value
• B)Number of true negatives
• C)Positive predictive value
• D)Sensitivity
• E)Specificity

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Definitions:

Seasoned Equity Offering

When a company with publicly traded shares issues additional shares. Also known as a “secondary” or “follow-on” offering.

Primary Market

The primary market is the financial market where new securities are issued and sold for the first time, directly from the issuer.

Secondary Market

A marketplace where investors buy and sell securities or assets that have been previously issued, often through exchanges or over-the-counter markets.

Equity Carve-Outs

The process by which a parent company sells a portion of the equity in a subsidiary to public investors.