A 6-Year-Old Girl with Chronic Anemia Requiring Repeated Blood Transfusions

question 62

Multiple Choice

A 6-year-old girl with chronic anemia requiring repeated blood transfusions is undergoing genetic testing.  The patient's mother and older sibling have a history of mild anemia.  Her peripheral blood smear shows hypochromic, microcytic red blood cells, and hemoglobin electrophoresis reveals a predominance of hemoglobins F and A2.  Sequencing of the β-globin gene is performed using the patient's erythroblast DNA.  A schematic representation of the gene and its transcribed RNA is shown in the image below. The base sequence indicated by the bold red arrow is responsible for which of the following functions?

• A)Enhancement of transcription
• B)Initiation of transcription
• C)Initiation of translation
• D)Repression of transcription
• E)Termination of transcription

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Definitions:

Internal Characteristics

Traits or features that originate within an individual or entity, defining their innate qualities or attributes.

Dependency Theorists

Scholars who argue that economic disparities between nations arise from the exploitation of poorer countries by wealthier ones, leading to a state of dependency.

Multinational Corporations

Entities that operate in multiple countries beyond their home base, usually to maximize market reach and optimize production costs.

Rich Countries

Nations with high gross domestic product (GDP) per capita, indicating a high level of economic prosperity and standard of living.