A 41-Year-Old Man with Trisomy 21 Is Evaluated in the Clinic

question 12

Multiple Choice

A 41-year-old man with trisomy 21 is evaluated in the clinic due to cognitive decline.  The patient has a history of moderate intellectual disability, but his higher cognitive functions have become progressively impaired in the past several years.  He previously volunteered at a community library but recently lost his position as he could no longer perform his duties.  The patient is now completely dependent on a caregiver for assistance with his activities of daily living such as getting dressed, bathing, and using the toilet.  The patient keeps wandering in the group home and has become lost on several occasions.  Which of the following is most likely to be increased in this patient?

• A)Amyloid A protein
• B)Amyloid precursor protein
• C)Apolipoprotein E epsilon 4
• D)CAG trinucleotide repeats
• E)Islet amyloid polypeptide

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Definitions:

Impression Management

The conscious or unconscious attempt by individuals to influence how others perceive them.

Flattery

The act of giving excessive praise or compliments, often to gain favor or advantage.

Favors

Acts of kindness beyond what is due or usual, often done to gain advantage or as a gesture of goodwill.

Personal Distortion

The alteration of reality based on an individual's perceptions, biases, and personal experiences, often leading to misinterpretation of information.