A 19-Year-Old Woman Is Evaluated for New Onset Generalized Tonic-Clonic

question 99

Multiple Choice

A 19-year-old woman is evaluated for new onset generalized tonic-clonic seizures.  For the past several years, she has also been having erratic jerks of her arms and legs, and intermittent muscle weakness.  The girl has multiple family members with similar symptoms.  Neurological examination reveals decreased sensation in the lower extremities and a broad-based gait.  Skeletal muscle biopsy shows ragged, red-appearing muscle fibers.  Further analysis reveals that the patient's symptoms are due to a mutation affecting extranuclear DNA.  Which of the following pedigrees is most likely to represent this patient's family history? (The arrow points to the patient.)

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Definitions:

Jeffersonian Party

An early American political party founded by Thomas Jefferson and James Madison around the 1790s that advocated for a decentralized government and agricultural society; also known as the Democratic-Republican Party.

Jeffersonian Republicans

A political ideology from the early United States advocating for limited federal government and agrarian democracy, associated with Thomas Jefferson.

National Government

The centralized political authority that governs an entire nation, as opposed to local or regional levels of government.

Incumbent

The current holder of a political office or position.