A 6-Year-Old Girl with Chronic Anemia Requiring Repeated Blood Transfusions

question 62

Multiple Choice

A 6-year-old girl with chronic anemia requiring repeated blood transfusions is undergoing genetic testing.  The patient's mother and older sibling have a history of mild anemia.  Her peripheral blood smear shows hypochromic, microcytic red blood cells, and hemoglobin electrophoresis reveals a predominance of hemoglobins F and A2.  Sequencing of the β-globin gene is performed using the patient's erythroblast DNA.  A schematic representation of the gene and its transcribed RNA is shown in the image below. The base sequence indicated by the bold red arrow is responsible for which of the following functions?

• A)Enhancement of transcription
• B)Initiation of transcription
• C)Initiation of translation
• D)Repression of transcription
• E)Termination of transcription

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Definitions:

Nonbreaching Party

The party in a contract that has not failed to fulfill any contractual obligations, as opposed to the party that has breached the contract.

Duty of Performance

An obligation of a party in a contract to complete the tasks, obligations, or services as agreed upon in the contract.

Uncertain Event

An event whose occurrence or outcome is not known or predictable with certainty, often associated with risk assessment.

Condition

A stipulation or requirement in a contract that must be met for the contract to be fully enforceable.