Researchers Are Investigating the Use of Immune Checkpoint Inhibitors for the Treatment

question 104

Multiple Choice

Researchers are investigating the use of immune checkpoint inhibitors for the treatment of advanced colorectal cancer.  They find that this therapy is more effective in patients with DNA mismatch-repair deficiency compared to patients with an intact mismatch-repair mechanism.  Which of the following most likely explains the improved efficacy of the drug in the first group of patients?

• A)Higher burden of tumor neoantigens
• B)Increased MHC class I expression in tumor cells
• C)Increased number of regulatory T cells
• D)Increased synthesis of metalloproteinases
• E)Lower frequency of DNA mutations

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