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A 55-Year-Old Man Is Evaluated Due to a Nonhealing Left

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A 55-year-old man is evaluated due to a nonhealing left forearm wound.  The patient had an excisional biopsy of a suspicious skin lesion at the site of the wound several weeks ago.  He has a history of uncontrolled type 2 diabetes mellitus and hypertension.  Vital signs are within normal limits.  Physical examination shows a 2.5-cm wound surrounded by erythema on the left forearm.  Upregulation of which of the following would most likely improve fibroblast proliferation and reepithelization in this nonhealing wound?

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