Researchers Are Investigating the Use of Immune Checkpoint Inhibitors for the Treatment

question 104

Multiple Choice

Researchers are investigating the use of immune checkpoint inhibitors for the treatment of advanced colorectal cancer.  They find that this therapy is more effective in patients with DNA mismatch-repair deficiency compared to patients with an intact mismatch-repair mechanism.  Which of the following most likely explains the improved efficacy of the drug in the first group of patients?

• A)Higher burden of tumor neoantigens
• B)Increased MHC class I expression in tumor cells
• C)Increased number of regulatory T cells
• D)Increased synthesis of metalloproteinases
• E)Lower frequency of DNA mutations

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Definitions:

Unconditional Response

Unconditional response is a term that may be intended for "unconditioned response," which is an automatic, natural reaction to a stimulus in behavioral psychology.

Conditional Response

A learned response to a previously neutral stimulus that, after becoming associated with an unconditioned stimulus, triggers a conditioned reaction.

Unconditional Stimulus

In classical conditioning, a stimulus that naturally and automatically triggers a reflexive response without the need for prior learning.

Temperament Stability

Describes the extent to which individual differences in disposition or behavior style are consistent across time and situation.