An 18-Year-Old Man Is Admitted to the Hospital with Cough

question 436

Multiple Choice

An 18-year-old man is admitted to the hospital with cough, fever, and hypoxemia.  Despite multiple intravenous antibiotics and frequent chest physiotherapy, the patient decompensates and is transferred to the intensive care unit for mechanical ventilation.  Sputum cultures grow >100,000 colony-forming units of a non-lactose-fermenting gram-negative rod.  After several days, the patient dies of overwhelming pneumonia complicated by respiratory failure.  Since age 1, he had been hospitalized for recurrent episodes of multi-lobar pneumonia, sinusitis, and poor growth.  On autopsy, both vas deferens are absent.  Which of the following findings is also likely to be present on autopsy?

• A)Distension and obstruction of pancreatic ducts
• B)Lobar sequestration
• C)Lymphocytic infiltrate of pancreatic islet cells
• D)Nodular lymphoid hyperplasia in the intestine
• E)Situs inversus

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Definitions:

Genotype

The genetic makeup of an organism, determining inherited characteristics.

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Monozygotic

Refers to twins that are genetically identical, originating from a single fertilized egg that splits into two.

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Referring to twins that are born from two different eggs fertilized by two different sperm cells, resulting in siblings that are genetically as similar as any other brothers or sisters.