A 34-Year-Old Man Is Evaluated for Elevated Liver Aminotransferases

question 157

Multiple Choice

A 34-year-old man is evaluated for elevated liver aminotransferases.  The patient has no chronic medical conditions but has a history of injection drug use.  Family history is notable for liver cirrhosis in his mother.  Ultrasonography-guided liver biopsy is performed.  Histopathology demonstrates marked panlobular mononuclear cell infiltration that cross into adjacent lobules.  Occasional intensely eosinophilic round bodies are seen scattered amongst the hepatic parenchyma.  Which of the following is the most likely cause of the latter histopathological finding in this patient?

• A)Coagulative necrosis due to a toxin
• B)Cytotoxic T-cell-mediated apoptosis
• C)Intracellular pigment accumulation
• D)Intracytoplasmic cytokeratin deposition
• E)Small foci of fibrinoid necrosis
• F)Stellate cell activation into myofibroblast

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Definitions:

Polygraph

A polygraph, or lie detector test, measures physiological responses to questions to determine truthfulness.

Parasympathetic Nervous System

Part of the autonomic nervous system that helps the body conserve energy and promotes relaxation and digestion.

Somatic Nervous System

A component of the peripheral nervous system that controls voluntary movements of the body's muscles.

Central Nervous System

The part of the nervous system consisting of the brain and spinal cord, which integrates information received from the body and coordinates activity.