A 23-Year-Old Man Comes to the Office Due to a Rapidly

question 112

Multiple Choice

A 23-year-old man comes to the office due to a rapidly enlarging left jaw mass that has developed over the past several weeks.  The patient is a political refugee from East Africa.  He has no known medical problems and takes no medications.  Temperature is 37.1 C (98.8 F) .  Physical examination shows a large left-sided tumor on his jaw with surrounding lymphadenopathy but no erythema or warmth.  The rest of the examination is unremarkable.  HIV testing is negative.  The lesion is biopsied, and numerous mitotic figures and apoptotic bodies are observed on histopathologic examination.  Which of the following genetic features is most likely to be present in this tissue?

• A)BCL2 overexpression
• B)BCR-ABL rearrangement
• C)c-Myc oncogene overexpression
• D)n-Myc oncogene overexpression
• E)Tyrosine kinase activation

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Definitions:

Matched Pairs

refers to a design in experiments where each case has a unique counterpart for comparison, minimizing variability.

Interval

A range of numbers between two set points, often used in mathematics and statistics to specify subsets of the real number line.

Chi-Squared Distribution

A distribution that represents the distribution of the sum of the squares of k independent standard normal random variables.

P-Value

The chance of encountering test outcomes as significant as or more than what is actually seen, assuming that the null hypothesis holds.