A 56-Year-Old Man Is Brought to the Emergency Department with New-Onset

question 398

Multiple Choice

A 56-year-old man is brought to the emergency department with new-onset tonic-clonic seizures.  His past medical history is unremarkable.  The patient recently has had right-sided headaches and has taken acetaminophen with some relief.  MRI of the brain reveals several round lesions in the right temporal lobe.  After initial evaluation, a stereotactic biopsy of one of the lesions is performed.  The biopsy results show neoplastic tissue containing a mutation in the gene that encodes BRAF, a protein kinase.  The point mutation results in a valine → glutamic acid substitution at position 600 of the protein.  Which of the following is the most likely diagnosis?

• A)Glioblastoma
• B)Melanoma
• C)Prostate cancer
• D)Renal cell carcinoma
• E)Small cell lung cancer

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Definitions:

Forward Contract

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Visual representations of the detailed sequence of operations and flow of materials through a system or process.