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A 53-Year-Old Man Comes to the Physician with Progressively Worsening

question 613

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A 53-year-old man comes to the physician with progressively worsening anorexia and abdominal discomfort.  He has lost 14 kg (31 lb) since the onset of his symptoms about 4 months ago.  Physical examination demonstrates nontender hepatomegaly.  Laboratory studies show an elevated serum alkaline phosphatase level and a marginally elevated alanine aminotransferase level.  A CT scan of the abdomen with oral and intravenous contrast is shown below. A 53-year-old man comes to the physician with progressively worsening anorexia and abdominal discomfort.  He has lost 14 kg (31 lb)  since the onset of his symptoms about 4 months ago.  Physical examination demonstrates nontender hepatomegaly.  Laboratory studies show an elevated serum alkaline phosphatase level and a marginally elevated alanine aminotransferase level.  A CT scan of the abdomen with oral and intravenous contrast is shown below.   Which of the following is the most likely diagnosis? A) Hepatic adenoma B) Hepatic angiosarcoma C) Hepatoblastoma D) Hepatocellular carcinoma E) Intrahepatic cholangiocarcinoma F) Metastatic liver disease Which of the following is the most likely diagnosis?

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Definitions:

Region of Rejection

The range of values in a statistical test for which the null hypothesis is rejected.

Statistic

A statistic is a numerical measurement describing some characteristic of a sample, which is a subset of the population data.

Research Hypothesis

An educated guess or prediction made for the purpose of testing through scientific research, stating a potential outcome or relationship.

Critical Values

Thresholds in hypothesis testing which, if exceeded by the test statistic, indicate that the null hypothesis can be rejected.

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