An 8-Year-Old Boy Comes to the Office Due to a Mass

question 372

Multiple Choice

An 8-year-old boy comes to the office due to a mass in the right mandible.  His family first noticed it a few months ago, and it has grown rapidly.  He has had no fevers, chills, cough, or weight loss.  The patient and his family recently immigrated to the United States from East Africa.  He has no known medical problems.  Temperature is 37 C (98.6 F) .  Physical examination shows a large tumor on the right mandible with palpable regional lymphadenopathy.  A biopsy of the lesion is performed.  Histopathologic examination shows a diffuse infiltrate of lymphoid cells with numerous mitotic figures; interspersed macrophages with clear cytoplasm are also seen.  These lymphoid cells most likely have a chromosomal translocation that directly alters which of the following processes?

• A)Apoptosis inhibition
• B)DNA repair
• C)Regulation of G1 to S-phase transition
• D)Transcription activation
• E)Tyrosine kinase upregulation

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Definitions:

Geographical

Related to or based on the physical features, location, and characteristics of the earth or a specific area.

Individuals

Refers to single human beings, considered separately from a group or society.

Teams

Groups of people working together towards a common goal, often characterized by collaborative effort and shared responsibilities.

Quicker

Pertains to achieving or performing something in a shorter amount of time or more rapidly.