A 26-Year-Old Man Is Brought to the Emergency Department After

question 582

Multiple Choice

A 26-year-old man is brought to the emergency department after a high-speed motorcycle collision.  The patient was thrown several feet after his motorcycle collided with a car.  On arrival, he is profoundly comatose.  A CT scan of the head performed within an hour of the event shows no abnormalities.  The patient dies several hours later, and autopsy examination is performed.  Brain histopathology shows widespread axonal swelling, predominantly at the gray-white junction.  Immunohistochemical staining of these axons reveals accumulation of alpha-synuclein and amyloid precursor proteins.  Which of the following is the most likely cause of these observed findings?

• A)Diffuse cerebral hypoperfusion
• B)Disruption of the bridging cortical veins
• C)Glutamate-mediated neuronal injury
• D)Interruption of the white matter tracts
• E)Secondary microvascular spasm

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Definitions:

Specialization

The process of focusing on and becoming an expert in a particular subject or skill.

Standardization

The process of implementing and developing technical standards to ensure uniformity, compatibility, safety, repeatability, or quality among products, services, or processes.

Centralization

The concentration of decision-making power and authority in the hands of a central body or a few individuals within an organization.

Formalization

The process of creating formal rules and procedures to standardize organizational activities and decisions.