An 18-Year-Old Man Is Evaluated Due to 3 Months of Lower

question 279

Multiple Choice

An 18-year-old man is evaluated due to 3 months of lower extremity pain.  The pain is persistent and present both day and night.  He has no fever, chills, or history of leg trauma.  Imaging shows an expansile lesion of the distal femur.  Surgical resection is performed, and the specimen is shown below. Mutations involving which of the following genes are most likely present in this patient?

• A)BRAF
• B)HER2
• C)KRAS
• D)RB1
• E)RET

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Definitions:

Successive Approximations

A behavioral training process that rewards actions that progressively more closely resemble the desired behavior.

Generalization

The tendency to respond in the same way to different but similar stimuli.

Discrimination

Unjust or prejudicial treatment of people based on characteristics such as race, age, sex, or disability.

Generalization

The process in which the effects of a learned behavior spread from the original situation to new situations or stimuli that are similar.