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A Newborn Is Evaluated for Cyanosis Immediately After Birth

question 165

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A newborn is evaluated for cyanosis immediately after birth.  On examination, oxygen saturation is 70% in all 4 extremities and does not change despite 100% oxygen administration.  The patient's lungs are clear to auscultation, and there are no heart murmurs or gallops.  Peripheral pulses are normal.  A chest radiograph reveals clear lungs and a normal cardiac silhouette but a narrowed mediastinal shadow.  Which of the following is the most likely cause of cyanosis in this patient?

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Definitions:

Oxaloacetate

A four-carbon molecule that plays a vital role in the citric acid cycle (Krebs cycle) and gluconeogenesis, involved in energy production and glucose synthesis.

Anaerobic Pathways

Anaerobic pathways are biochemical processes that enable cells to produce energy without the need for oxygen.

Glycogen

Highly branched polysaccharide of glucose monomers. Principal form of stored sugars in animals.

Liver Cells

Liver cells, also known as hepatocytes, are the main cell type found in the liver, performing various functions including detoxification, protein synthesis, and the production of biochemicals necessary for digestion.

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