A Group of Investigators Is Studying the Mechanisms of Signal

question 107

Multiple Choice

A group of investigators is studying the mechanisms of signal transduction involved in the pathogenesis of type 2 diabetes mellitus.  Their research focuses on the intracellular signaling cascade that begins when insulin binds to the insulin receptor.  In a series of experiments, they demonstrate that pre-treatment with tumor necrosis factor alpha (TNF-α) results in decreased insulin-mediated glucose uptake.  This effect of TNF-α is most likely mediated through upregulation of which of the following processes?

• A)Cyclic AMP hydrolyzation
• B)Phosphatidylinositol cleavage
• C)Proline residue hydroxylation
• D)Serine residue phosphorylation
• E)Stimulation of peroxisome proliferator-activated receptor

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