A Study Was Conducted to Determine the Utility of Adjunctive

question 104

Multiple Choice

A study was conducted to determine the utility of adjunctive therapy in bacterial meningitis.  Patients with acute bacterial meningitis whose cerebrospinal fluid (CSF) analysis showed gram-positive diplococci were divided into 2 groups.  The first (control) group was given systemic antibiotics only, and the second (experimental) group was given dexamethasone followed by systemic antibiotics.  Compared to the control group, patients in the experimental group developed fewer neurologic sequelae and had a lower risk of death.  The experimental patients most likely benefited from the use of this drug due to which of the following?

• A)Decreased cerebral metabolic activity
• B)Decreased inflammatory response in the CSF
• C)Increased antibiotic penetration into the CSF
• D)Increased bone marrow release of neutrophils
• E)Increased plasma glucose for cerebral use

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