Researchers Are Conducting a Study to Determine the Effectiveness of a Novel

question 257

Multiple Choice

Researchers are conducting a study to determine the effectiveness of a novel humanized monoclonal antibody in patients with metastatic colorectal cancer.  This medication works by binding to the programmed cell death-1 receptor on T cells to block its ligands from binding.  They find this therapy is most effective in patients with a high degree of microsatellite instability or defects in DNA mismatch repairs.  Which of the following best explains the favorable drug effect in this subset of patients?

• A)Higher expression of P-glycoprotein
• B)Higher number of cancer neoantigens
• C)Higher rate of KRAS mutations
• D)Higher rate of p53 mutations
• E)More intense desmoplastic reaction

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Definitions:

Aleutian Islands

A chain of volcanic islands located in the northern Pacific Ocean, extending from Alaska towards Russia.

Bering Sea

A marginal sea of the Pacific Ocean between Alaska and Russia, known for its deep basin and diverse marine life.

Suspended Sediment

Particles of soil or minerals that are carried by water and remain floating in the column rather than sinking to the bottom.

Northeastern Australia

A region of Australia located in the northeast part of the continent, known for its diverse ecosystems, including the Great Barrier Reef.