A 67-Year-Old Man Is Evaluated for Persistent Lower Back Pain

question 422

Multiple Choice

A 67-year-old man is evaluated for persistent lower back pain and fatigue.  The patient has no other medical conditions and takes no medications.  Laboratory testing shows anemia and renal dysfunction.  Serum total protein levels are elevated, and electrophoresis of the serum proteins reveals a narrow spike in the gamma globulin region.  A subsequent bone marrow biopsy shows abnormal marrow cells.  A medication that blocks cellular proteasome action is administered.  This treatment is most likely to cause which of the following effects on the abnormal cells?

• A)Augmented cytotoxic T-cell response
• B)Decreased DNA methylation
• C)Impaired RNA splicing
• D)Improved differentiation
• E)Increased apoptosis

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Definitions:

Corporate Codes

Rules, guidelines, and standards adopted by companies to govern behavior and ensure ethical practice and compliance within the organization.

Public Pressure

The influence exerted by the general public or specific groups to sway the actions or decisions of individuals, organizations, or governments.

Relative Bargaining Power

The comparative strength or leverage that one party has over another in negotiation situations, often determined by alternative options, resources, or strategic positions.

Financialization

The process by which financial markets, financial institutions, and financial elites gain greater influence over economic policy and economic outcomes.