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A 45-Year-Old Man Comes to the Clinic Due to Recurrent

question 116

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A 45-year-old man comes to the clinic due to recurrent palpitations accompanied by chest discomfort and shortness of breath.  A year ago, he was diagnosed with paroxysmal atrial fibrillation treated with rate control using a beta blocker.  Past medical history is also significant for hypertension and obesity.  Echocardiogram shows left atrial enlargement, normal left ventricular ejection fraction, and no significant valvular disease.  24-hour Holter monitoring reveals bursts of atrial fibrillation associated with the patient's symptoms.  He is initiated on dofetilide to maintain normal sinus rhythm.  This medication exerts its main effect on which portion of the action potential curve? A 45-year-old man comes to the clinic due to recurrent palpitations accompanied by chest discomfort and shortness of breath.  A year ago, he was diagnosed with paroxysmal atrial fibrillation treated with rate control using a beta blocker.  Past medical history is also significant for hypertension and obesity.  Echocardiogram shows left atrial enlargement, normal left ventricular ejection fraction, and no significant valvular disease.  24-hour Holter monitoring reveals bursts of atrial fibrillation associated with the patient's symptoms.  He is initiated on dofetilide to maintain normal sinus rhythm.  This medication exerts its main effect on which portion of the action potential curve?   A) A B) B C) C D) D E) E


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