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A 53-Year-Old Man Comes to the Office Due to Uncontrolled

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A 53-year-old man comes to the office due to uncontrolled type 2 diabetes mellitus.  Three years ago, the patient was diagnosed with diabetes and started on metformin and lifestyle modification.  In the past year, his hemoglobin A1c level has been steadily rising.  Blood pressure is 145/90 mm Hg.  BMI is 37 kg/m2.  Laboratory results are normal except for a fasting plasma glucose of 155 mg/dL and a hemoglobin A1c level of 8%.  Additional treatment with canagliflozin is initiated.  Over the next several days, which of the following changes are most likely to occur in this patient due to the new medication?
A 53-year-old man comes to the office due to uncontrolled type 2 diabetes mellitus.  Three years ago, the patient was diagnosed with diabetes and started on metformin and lifestyle modification.  In the past year, his hemoglobin A1c level has been steadily rising.  Blood pressure is 145/90 mm Hg.  BMI is 37 kg/m<sup>2</sup>.  Laboratory results are normal except for a fasting plasma glucose of 155 mg/dL and a hemoglobin A1c level of 8%.  Additional treatment with canagliflozin is initiated.  Over the next several days, which of the following changes are most likely to occur in this patient due to the new medication?   A) A B) B C) C D) D E) E


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