A 28-Year-Old Man Comes to the Emergency Department Due to Progressive

question 391

Multiple Choice

A 28-year-old man comes to the emergency department due to progressive abdominal pain.  Although he has had mild abdominal cramps in the past, he has never before experienced anything this severe.  The patient has 8-10 watery stools a day, weight loss, fatigue, and lethargy.  Temperature is 38.3 C (100.9 F) , blood pressure is 125/82 mm Hg, pulse is 95/min, and respirations are 14/min.  The abdomen is tender to palpation without rebound or guarding.  Abdominal CT scan reveals inflammatory changes affecting the ascending colon, sigmoid colon, and terminal ileum.  Intestinal biopsy reveals the following: Effective treatment of this patient's condition could be achieved by targeting which of the following molecules?

• A)BCR-ABL protein tyrosine kinase
• B)CD20 lymphocyte antigen
• C)mTOR protein kinase
• D)Programmed cell death-1 protein
• E)Tumor necrosis factor-alpha

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Definitions:

Schizophrenia

An illness affecting the mind, leading to altered thinking patterns, sensory perceptions, emotional responses, and behavior in social contexts.

Negative Symptoms

Symptoms of schizophrenia and other psychosis-related disorders that involve the absence or diminution of normal behaviors or emotions, such as social withdrawal or lack of motivation.

Positive Symptoms

In schizophrenia, hallucinations, delusions, and disorganization in thought and behavior.

Neuroleptics

A class of medication primarily used to manage psychosis, particularly in schizophrenia and bipolar disorder.