A 70-Year-Old Man Develops Progressive Fatigue and Easy Bruising

question 171

Multiple Choice

A 70-year-old man develops progressive fatigue and easy bruising.  He has had unintentional weight loss and episodic fevers.  Physical examination shows splenomegaly and enlarged lymph nodes in the cervical, axillary, and inguinal regions.  Complete blood count reveals anemia, thrombocytopenia, and leukocytosis.  Peripheral blood smear shows an increased number of small, mature-appearing, abnormal lymphocytes, which express CD20 and kappa light chains.  During treatment, the patient receives an agent that directly binds and inhibits BCL-2 protein.  Which of the following is the most likely effect of this therapy on the abnormal cells?

• A)Accumulation of ubiquitinated intracellular proteins
• B)Greater susceptibility to cytotoxic T cells
• C)Increased activation of caspases
• D)Increased single-strand DNA breaks
• E)Interruption of cell growth in S phase
• F)Targeting of antibody-dependent cellular cytotoxicity

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Definitions:

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A theory that suggests that, in the absence of transaction costs and other barriers, identical goods and services in different countries should have the same price when expressed in a common currency.

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The amount one currency is valued at when translated into another currency.

Kilogram

The base unit of mass in the International System of Units (SI), equivalent to 1,000 grams or approximately 2.20462 pounds.

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