A 12-Year-Old Boy Is Evaluated Due to Fever, Fatigue, and Easy

question 383

Multiple Choice

A 12-year-old boy is evaluated due to fever, fatigue, and easy bruising.  Physical examination shows pallor, generalized lymphadenopathy, and bone tenderness.  Laboratory evaluation reveals anemia, thrombocytopenia, and leukocytosis with atypical lymphoblasts.  Bone marrow biopsy is consistent with acute lymphoblastic leukemia.  The patient is treated with combination chemotherapy, and 6-mercaptopurine is administered for maintenance of remission.  Which of the following enzymes inactivates this drug?

• A)Adenosine deaminase
• B)Dihydrofolate reductase
• C)Hypoxanthine-guanine phosphoribosyltransferase
• D)Monoamine oxidase
• E)P-450 mixed-function oxidase
• F)Topoisomerase II
• G)Xanthine oxidase

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Definitions:

Ventral Medial Geniculate Nucleus

The ventral medial geniculate nucleus is a part of the auditory thalamus involved in the processing and relaying of auditory information from the ears to the auditory cortex of the brain.

Inputs

Signals or data received by a system, which are then processed to generate an output.

Inner Hair Cells

Inner hair cells are the sensory cells located in the cochlea of the inner ear, playing a critical role in sound transduction by converting mechanical sound vibrations into electrical signals to the brain.

Human Cochlea

A spiral-shaped, fluid-filled inner ear structure, essential for converting sound wave vibrations into electrical signals for the brain.