A 28-Year-Old Man Is Undergoing a Laparoscopic Appendectomy for Acute

question 340

Multiple Choice

A 28-year-old man is undergoing a laparoscopic appendectomy for acute appendicitis.  Shortly after induction of anesthesia, the surgeon reports difficulty maintaining abdominal insufflation due to severe muscle rigidity.  Pulse is 130/min and the ECG tracing shows sinus tachycardia.  Physical examination reveals diffuse muscle stiffness.  Inhibition of which of the following is most likely to improve this patient's condition?

• A)Acetylcholine degradation in cholinergic synapses
• B)Alpha-receptor-mediated sympathetic activity
• C)GABA-mediated neuron hyperpolarization
• D)Ligand-receptor interaction in cholinergic synapses
• E)Sarcoplasmic calcium release in skeletal muscles

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