MPTP Is a Toxic Substance That Induces a Parkinsonism-Like Syndrome

question 65

Multiple Choice

MPTP is a toxic substance that induces a Parkinsonism-like syndrome by destroying dopaminergic neurons in the CNS.  A series of experiments demonstrated that MPTP per se is minimally toxic.  Actually, it is a metabolite of MPTP, produced by MAO type B and called MPP+, that causes the neurological damage.  Pretreatment by which of the following agents would minimize the damage induced by MPTP consumption?

• A)Amantadine
• B)Levodopa
• C)Levodopa/carbidopa
• D)Selegiline
• E)Pergolide

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