Researchers Investigating the Effects of Heart Failure on the Pharmacokinetics

question 533

Multiple Choice

Researchers investigating the effects of heart failure on the pharmacokinetics of antidiabetic medications develop a cohort of experimental animals with anthracycline-induced heart failure.  The experimental animals are then administered an oral dose of metformin, and serum levels are monitored over time.  The test is repeated in control animals with normal heart function and the results are shown below: Which of the following best explains the change in serum metformin levels seen in the experimental animals?

• A)Cytochrome P450 inhibition
• B)Decreased renal blood flow
• C)Extracellular fluid accumulation
• D)Hepatic venous congestion
• E)Intestinal wall edema

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Definitions:

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The center of a target, often denoting a point of perfect accuracy or the achievement of a goal with precision.

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Unaffected by other variables; capable of existing or operating separately.

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The sport, practice, or skill of using a bow to shoot arrows.

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The quantification of the probability of an event happening, represented as a numerical value ranging from 0 to 1.