A 59-Year-Old Man Who Is Being Treated for Hypercholesterolemia, Diabetes

question 381

Multiple Choice

A 59-year-old man who is being treated for hypercholesterolemia, diabetes, and hypertension comes to the physician for a scheduled follow-up visit three weeks after starting a new medication.  He has no new complaints.  Blood work drawn yesterday shows an interim increase in potassium from 4.8 mEq/L to 5.2 mEq/L and a creatinine elevation from 1.2 mg/dL to 1.6 mg/dL.  Administration of which of the following drugs is most likely responsible for the change in this patient's renal function?

• A)Lisinopril
• B)Metoprolol
• C)Atorvastatin
• D)Hydrochlorothiazide
• E)Furosemide
• F)Metformin
• G)Prazosin

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Definitions:

Dosage Compensation

A mechanism that ensures equal expression of genes from the sex chromosomes despite the difference in chromosome number between males and females.

X-Linked Gene

A gene located on the X chromosome, with its expression and associated traits often differentially presented in males and females due to X-chromosome inactivation or hemizygosity in males.

Independent Assortment

The principle describing how different genes independently separate from one another when reproductive cells develop.

Paired Factors

Fundamental entities in genetics that occur in pairs and determine specific characteristics or traits of an organism.