A 44-Year-Old Man Comes to the Office Due to Increasing

question 188

Multiple Choice

A 44-year-old man comes to the office due to increasing shortness of breath.  While climbing the stairs to his second-floor apartment, the patient must now stop halfway to catch his breath.  He has a history of nonischemic cardiomyopathy and chronic heart failure with reduced ejection fraction.  After evaluation, treatment with a new medication is begun that improves his symptoms by increasing urine output and decreasing peripheral vascular resistance.  The medication works by inhibiting a metalloprotease to prolong the action of endogenous polypeptides.  These polypeptides are most likely secreted by which of the following cell types?

• A)Adrenal zona glomerulosa cells
• B)Cardiomyocytes
• C)Hepatic stellate cells
• D)Myocardial Purkinje fibers
• E)Renal juxtaglomerular cells
• F)Vascular endothelial cells

---

Definitions:

Scientific Method

A systematic process of inquiry involving observation, hypothesis formulation, experimentation, and conclusion to test scientific theories and gain knowledge.

Research Method

The systematic approach to collecting, analyzing, and interpreting data in order to increase understanding of a topic or issue.

Testable Hypothesis

A hypothesis that can be supported or refuted through experimentation or observation, making it possible to draw conclusions.

Hormones

Chemical messengers produced by the endocrine glands that regulate various bodily functions by traveling through the bloodstream to organs and tissues.