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A 36-year-old woman comes to the emergency department due to right lower leg pain and ankle edema. Her symptoms began 2 days ago after a 14-hour flight from India. The patient has had no leg trauma, fever, chest pain, or shortness of breath. She has a history of asthma and takes inhaled albuterol as needed. The patient has no family history of blood clots.
Temperature is 36.8 C (98.2 F) , blood pressure is 142/72 mm Hg, pulse is 98/min, and respirations are 16/min. BMI is 26 kg/m2. Cardiopulmonary examination shows no abnormalities. There is 2+ right lower extremity pitting edema extending to the mid-calf, and right foot dorsiflexion results in right calf pain. Left lower extremity examination is normal. Stool guaiac is negative. Laboratory results are as follows: Compression ultrasonography of the right lower extremity shows no evidence of deep venous thrombosis. D-dimer is 65 µg/mL (normal: <0.5) .
Which of the following is the most appropriate next step in management of this patient?
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