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A 62-year-old man is brought to the emergency department because of watery diarrhea, skin rash, and confusion. He has had diarrhea for the past 1-2 days and took some over-the-counter medicines. He returned from a cruise to Mexico 4 days ago. He ate shellfish and raw oysters with fried rice at a local restaurant 2 days ago.
His other medical problems include alcoholic liver cirrhosis, type 2 diabetes mellitus, hypertension, and mild chronic kidney disease. His medications include spironolactone, long-acting insulin, and propranolol. He is an ex-smoker and drinks 1-2 cans of beer on weekends. He occasionally smokes crack cocaine and marijuana.
His temperature is 38.9 C (102 F) , blood pressure is 70/30 mm Hg, pulse is 124/min, and respirations are 22/min. Examination shows bilateral basal crackles. The abdomen is distended and non-tender. His skin shows multiple bullous lesions.
Laboratory results are as follows: Despite aggressive fluid resuscitation and antibiotics, the patient dies in the emergency department.
Which of the following is most likely responsible for this patient's initial presentation?
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