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An 85-Year-Old Nursing Home Resident Is Brought to the Emergency

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An 85-year-old nursing home resident is brought to the emergency department due to worsening cough, difficulty breathing, and decreased responsiveness for 3 days.  Medical conditions include hypertension, type 2 diabetes mellitus, and dementia.  Following evaluation that reveals leukocytosis and lung infiltrates, the patient's respiratory distress progressively worsens.  Endotracheal intubation is performed; mechanical ventilation is begun; the patient is given intravenous fluids and antibiotics; a central venous catheter is placed; and she is admitted to the intensive care unit (ICU) .
In the ICU, the patient requires increasing ventilatory support with elevated airway pressures.  Temperature is 35.6 C (96 F) , blood pressure is 84/40 mm Hg, pulse is 112/min, and respirations are 16/min.  Pulse oximetry shows 92% on assist-control mode with a tidal volume of 300 mL, fraction of inspired oxygen (FiO2) of 60%, and positive end-expiratory pressure (PEEP) of 5 cm H2O.  Examination reveals decreased breath sounds on the right, rhonchi on the left, and normal S1 and S2.  The abdomen is soft and nontender.  There is no extremity edema.
Arterial blood gases and chest x-ray are shown below.
An 85-year-old nursing home resident is brought to the emergency department due to worsening cough, difficulty breathing, and decreased responsiveness for 3 days.  Medical conditions include hypertension, type 2 diabetes mellitus, and dementia.  Following evaluation that reveals leukocytosis and lung infiltrates, the patient's respiratory distress progressively worsens.  Endotracheal intubation is performed; mechanical ventilation is begun; the patient is given intravenous fluids and antibiotics; a central venous catheter is placed; and she is admitted to the intensive care unit (ICU) . In the ICU, the patient requires increasing ventilatory support with elevated airway pressures.  Temperature is 35.6 C (96 F) , blood pressure is 84/40 mm Hg, pulse is 112/min, and respirations are 16/min.  Pulse oximetry shows 92% on assist-control mode with a tidal volume of 300 mL, fraction of inspired oxygen (FiO<sub>2</sub>)  of 60%, and positive end-expiratory pressure (PEEP)  of 5 cm H<sub>2</sub>O.  Examination reveals decreased breath sounds on the right, rhonchi on the left, and normal S1 and S2.  The abdomen is soft and nontender.  There is no extremity edema. Arterial blood gases and chest x-ray are shown below.     Which of the following is the most appropriate next step in management of this patient? A) Increase the PEEP B) Insert chest tube C) Provide short-term neuromuscular paralysis D) Reposition the endotracheal tube E) Suction respiratory secretions An 85-year-old nursing home resident is brought to the emergency department due to worsening cough, difficulty breathing, and decreased responsiveness for 3 days.  Medical conditions include hypertension, type 2 diabetes mellitus, and dementia.  Following evaluation that reveals leukocytosis and lung infiltrates, the patient's respiratory distress progressively worsens.  Endotracheal intubation is performed; mechanical ventilation is begun; the patient is given intravenous fluids and antibiotics; a central venous catheter is placed; and she is admitted to the intensive care unit (ICU) . In the ICU, the patient requires increasing ventilatory support with elevated airway pressures.  Temperature is 35.6 C (96 F) , blood pressure is 84/40 mm Hg, pulse is 112/min, and respirations are 16/min.  Pulse oximetry shows 92% on assist-control mode with a tidal volume of 300 mL, fraction of inspired oxygen (FiO<sub>2</sub>)  of 60%, and positive end-expiratory pressure (PEEP)  of 5 cm H<sub>2</sub>O.  Examination reveals decreased breath sounds on the right, rhonchi on the left, and normal S1 and S2.  The abdomen is soft and nontender.  There is no extremity edema. Arterial blood gases and chest x-ray are shown below.     Which of the following is the most appropriate next step in management of this patient? A) Increase the PEEP B) Insert chest tube C) Provide short-term neuromuscular paralysis D) Reposition the endotracheal tube E) Suction respiratory secretions
Which of the following is the most appropriate next step in management of this patient?


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