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A 45-Year-Old Woman Comes to the Physician with Exertional Shortness

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A 45-year-old woman comes to the physician with exertional shortness of breath and lower-extremity swelling over the last 6 weeks.  She has no chest pain, dizziness, or orthopnea.  She also suffers from chronic diarrhea that has not responded to dietary modifications.  Colonoscopy with biopsies done 6 months ago was unremarkable.  The patient has been taking herbal supplements for hot flashes that she describes as severe.  She does not use tobacco or illicit drugs but does drink a few beers on weekends.
Her blood pressure is 142/80 mm Hg and pulse is 98/min.  Her body mass index is 26 kg/m2.  Purplish, blanching telangiectasias are seen on her upper lip and nose.  Jugular venous distention is present.  A 3/6 holosystolic murmur is heard at the lower sternum that increases with inspiration.  Lungs are clear to auscultation.  The liver is enlarged and pulsatile.  There is 2+ edema of both lower extremities.  The remainder of the examination is within normal limits.
Laboratory results are as follows:
A 45-year-old woman comes to the physician with exertional shortness of breath and lower-extremity swelling over the last 6 weeks.  She has no chest pain, dizziness, or orthopnea.  She also suffers from chronic diarrhea that has not responded to dietary modifications.  Colonoscopy with biopsies done 6 months ago was unremarkable.  The patient has been taking herbal supplements for hot flashes that she describes as severe.  She does not use tobacco or illicit drugs but does drink a few beers on weekends. Her blood pressure is 142/80 mm Hg and pulse is 98/min.  Her body mass index is 26 kg/m<sup>2</sup>.  Purplish, blanching telangiectasias are seen on her upper lip and nose.  Jugular venous distention is present.  A 3/6 holosystolic murmur is heard at the lower sternum that increases with inspiration.  Lungs are clear to auscultation.  The liver is enlarged and pulsatile.  There is 2+ edema of both lower extremities.  The remainder of the examination is within normal limits. Laboratory results are as follows:   Which of the following is the most likely diagnosis? A) Carcinoid syndrome B) Pheochromocytoma C) Systemic mastocytosis D) Systemic sclerosis E) VIPoma
Which of the following is the most likely diagnosis?


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