An Analysis of Results from 18,317 Patients Pooled from 5

question 426

Multiple Choice

An analysis of results from 18,317 patients pooled from 5 large randomized controlled trials on drug X revealed the following relative rates (RR) for drug X compared to the control:
RR of cardiovascular mortality = 0.90 (95% confidence interval [CI], 0.73-1.38)
RR of heart failure = 2.09 (95% CI, 1.52-2.88)
RR of myocardial infarction = 1.18 (95% CI, 0.86-1.31)
Based on the results of this meta-analysis, there is a statistically significant increase in which of the following events among patients taking drug X?

• A)Cardiovascular mortality and myocardial infarction
• B)Cardiovascular mortality only
• C)Heart failure and myocardial infarction
• D)Heart failure only
• E)Myocardial infarction only

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Definitions:

Yield

The income generated by an investment, often expressed as a percentage of the investment's cost or market value.

Basis Points

A financial measurement unit representing the percentage shift in the value or rate of a financial asset, which is equal to one hundredth of a percent.

Yield To Maturity

The total return anticipated on a bond if the bond is held until its maturity date, expressed as an annual rate.

Duration

A measure of the sensitivity of a bond's or fixed income portfolio's price to changes in interest rates, often used to manage interest rate risk.