A Large Multicenter Double-Blinded Randomized Placebo-Controlled Study Is Being Planned

question 863

Multiple Choice

A large multicenter double-blinded randomized placebo-controlled study is being planned to evaluate a new medication.  Primary endpoints addressing mortality benefits are chosen, and a comprehensive analysis strategy is specified, including for predefined subgroups.
In discussing the advantages of this study design, which of the following represents a benefit of randomization?

• A)Randomization can be performed at the level of subgroup analysis
• B)Randomization distributes known and unknown variables equally among the study groups
• C)Randomization ensures that the study results are statistically significant
• D)Randomization ensures that the study sample is representative of the population
• E)Randomization prevents group allocation concealment from study participants and investigators

Distinguish between material and immaterial breaches of contract and their eventual impact on the contractual relationship.

Learn the distinction between actual performance and substantial performance and their relevance in fulfilling contractual obligations.

Understand the conditions under which specific orders, like orders for specific performance, can be sought to enforce contract terms.

Acknowledge the effect of personal and unforeseeable circumstances (like illness or unforeseen incapacity) on the performance of contractual obligations.

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Definitions:

Table Alert

A notification or warning that is triggered based on specific conditions or criteria within a table.

Data Validation

The process of checking and ensuring that the data input into a database or spreadsheet meets specified criteria and is clean, correct, and useful.

Table Column

A vertical arrangement of data or information in a table, where each column is identified by a unique header.

Specify Data

The act of identifying and describing particular data elements or criteria that need to be met or included in a data set.