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A 78-year-old man comes to the office for routine follow-up. He had an ischemic stroke 8 months ago and has some residual weakness in his left leg. The patient had a fall 4 months ago without significant injuries, but his gait is somewhat unsteady. Medical history is significant for diet-controlled type 2 diabetes mellitus, hypertension, chronic kidney disease, and persistent atrial fibrillation. Current medications are lisinopril, metoprolol, atorvastatin, and low-dose aspirin. The patient has been treated with warfarin due to atrial fibrillation, but he found it difficult to follow frequent blood checks and stopped the therapy. He is a lifelong nonsmoker and does not drink alcohol. Despite leg weakness, he enjoys short walks in his yard every morning.
Blood pressure is 133/76 mm Hg, and pulse is 88/min and irregular. No murmurs are heard on cardiac auscultation, and there is no peripheral edema.
Laboratory results are as follows: Estimated glomerular filtration rate (eGFR) is 39 mL/min. ECG shows atrial fibrillation and voltage criteria for left ventricular hypertrophy.
Which of the following is the best therapy to offer this patient?
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