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A 65-Year-Old Man Is Evaluated for a 6-Month History of Unsteady

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A 65-year-old man is evaluated for a 6-month history of unsteady gait.  His balance has become so poor that he requires the use of a cane.  The patient also has paresthesias in his hands and feet, which started a year ago.  He has a medical history of lumbar spinal stenosis, hypertension, and hyperlipidemia.  The patient has a 30-pack-year smoking history and does not use alcohol or illicit drugs.
Blood pressure is 143/90 mm Hg and heart rate is 82/min.  Neurologic examination reveals a distal greater than proximal reduction in pain and temperature sensation, vibration, and proprioception in the lower and upper extremities.  Muscle bulk, tone, and strength are normal.  Ankle reflexes are absent with downgoing plantar responses.  His gait is high-stepping, and Romberg sign is positive.  Laboratory results are as follows:
A 65-year-old man is evaluated for a 6-month history of unsteady gait.  His balance has become so poor that he requires the use of a cane.  The patient also has paresthesias in his hands and feet, which started a year ago.  He has a medical history of lumbar spinal stenosis, hypertension, and hyperlipidemia.  The patient has a 30-pack-year smoking history and does not use alcohol or illicit drugs. Blood pressure is 143/90 mm Hg and heart rate is 82/min.  Neurologic examination reveals a distal greater than proximal reduction in pain and temperature sensation, vibration, and proprioception in the lower and upper extremities.  Muscle bulk, tone, and strength are normal.  Ankle reflexes are absent with downgoing plantar responses.  His gait is high-stepping, and Romberg sign is positive.  Laboratory results are as follows:   Which of the following tests is most likely to establish the diagnosis in this patient? A) Lumbar puncture B) Lyme disease serology C) MRI of the brain and spine D) Serum immunofixation electrophoresis E) Urine and blood for porphyrins Which of the following tests is most likely to establish the diagnosis in this patient?


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