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A 56-year-old man with a history of alcohol abuse is hospitalized due to aspiration pneumonia of the right lower lung. While being treated, he develops severe hypoxemia requiring transfer to the intensive care unit for initiation of mechanical ventilation. Temperature is 37.1 C (98.8 F) , blood pressure is 120/62 mm Hg, and pulse is 95/min. Pulmonary examination is significant for bilateral crackles. There is no jugular venous distension or peripheral edema. Repeat chest x-ray demonstrates diffuse, bilateral alveolar opacities.
Initial ventilator settings demonstrate a tidal volume of 510 mL (8 mL/kg of predicted body weight) , positive end-expiratory pressure of 10 cm H2O, respiratory rate of 35/min, and FiO2 of 80%. Tidal volume is reduced to 380 mL (6 mL/kg of ideal body weight) over several hours; the other ventilator parameters are unchanged. Plateau pressure is 27 cm H2O. Arterial blood gas results are as follows: What is the best next step in management of this patient?
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