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A 35-Year Old Man Comes to the Physician Because of Dyspnea

question 873

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A 35-year old man comes to the physician because of dyspnea on exertion over the last 3-4 months.  The dyspnea is more prominent when he plays tennis.  He has no symptoms at rest.  He denies chest pain, palpitations, or leg swelling.  His other medical problems include chronic low back pain and gastroesophageal reflux disease.  He has had local corticosteroid injections due to frequent left heel pain.  His current medications include ranitidine and ibuprofen daily, and occasional acetaminophen/codeine for back pain.
His blood pressure is 120/55 mm Hg, pulse is 56/min, and respirations are 12/min.  He is in no acute distress.  The lungs are clear to auscultation bilaterally.  His apical impulse is slightly displaced both inferiorly and laterally.  There is a normal S1 and S2.  An early decrescendo diastolic murmur is heard best at the left upper sternal border.  A third heart sound is present.  His pulses are 3+ and symmetric.  There is no peripheral joint inflammation or tenderness; range of motion is normal.  There are no skin rashes.
Chest x-ray shows normal lung fields, a moderately enlarged cardiac silhouette, and widening of the mediastinum.  The chest CT shows a dilated aortic root (4.4 cm) without evidence of dissection.
Which of the following is the most likely diagnosis?

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