A 35-Year-Old Caucasian Male with Aplastic Anemia Undergoes Bone Marrow

question 1635

Multiple Choice

A 35-year-old Caucasian male with aplastic anemia undergoes bone marrow transplantation.  The donor is an HLA-matched sibling.  Two weeks after the procedure, he develops a maculopapular pruritic rash that is predominantly found on his face, hands, and feet.  He also complains of diarrhea.  The stool is positive for occult blood.  Liver function tests are abnormal.  Which of the following is the most likely pathophysiologic mechanism of this patient's condition?

• A)Activation of the donor T lymphocytes
• B)Activation of the donor B-lymphocytes
• C)Activation of the host T lymphocytes
• D)Virus-induced lymphocyte proliferation
• E)Depression of the donor myelopoiesis

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Definitions:

Fear of Snakes

An intense, irrational fear of snakes, also known as ophidiophobia, often leading to avoidance behavior.

Monkey

A primate belonging to the group that typically has a tail and is smaller than an ape, often noted for high intelligence and agile movements.

Phobia

An extreme or irrational fear or aversion to something, often resulting in avoidance behavior and distress.

Systematic Desensitization

A therapeutic technique used to help individuals overcome phobias and anxiety, involving gradual exposure to the feared object or situation.