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A 54-year-old man is evaluated for erectile dysfunction. The patient has been having problems attaining and maintaining erections during sexual activity for the past 6 months. Prior to the development of this problem, he had an active and satisfactory sex life. The patient continues to have normal early-morning penile erections. Medical history is notable for hypertension, mixed hyperlipidemia, gastroesophageal reflux, and lumbar stenosis with a chronic right L4 radiculopathy. His current medications include ibuprofen, ranitidine, lisinopril, and atorvastatin. The patient smokes a pack of cigarettes daily and drinks alcohol only on social occasions. Blood pressure is 144/78 mm Hg and pulse is 80/min. BMI is 35 kg/m2. Physical examination shows normal body hair distribution and testicular size with no gynecomastia. Which of the following is the most likely cause of this patient's erectile dysfunction?
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