A Study of Patients with Metastatic Renal Cell Carcinoma (RCC)

question 887

Multiple Choice

A study of patients with metastatic renal cell carcinoma (RCC) compared the effectiveness of standard chemotherapy to a novel tyrosine kinase inhibitor (TKI) with activity against vascular endothelial growth factor in progression-free survival (primary end point) as first-line treatment.  Tumor response was significant in both groups at final follow-up (p < 0.05) .  The Kaplan-Meier survival curve for overall survival is shown below. Treatment-related adverse events such as diarrhea, nausea, vomiting, hypertension, hand-foot syndrome, asthenia, leukopenia, neutropenia, thrombocytopenia, lymphopenia, and increased lipase and uric acid occurred more frequently in the TKI group than in the standard chemotherapy group (p < 0.05) .  Based on the findings of this study, which of the following conclusions is justified?

• A)Either treatment can be recommended because there is no significant difference in outcomes between the 2 groups
• B)Neither treatment should be recommended because there is no significant difference in outcomes between groups
• C)Standard chemotherapy should be recommended because it is associated with lower rates of treatment-related adverse events
• D)TKI therapy should be recommended because its use resulted in longer overall survival estimates

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