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A 59-Year-Old Man Comes to the Office for Follow-Up

question 900

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A 59-year-old man comes to the office for follow-up.  He has a history of hypertension for which he takes 2 antihypertensive agents.  The patient has no other cardiovascular problems and does not smoke.  On examination, his blood pressure is 145/90 mm Hg and BMI is 25.4 kg/m2.  The remainder of the examination is unremarkable.  Laboratory studies show elevated fasting lipid levels, including LDL cholesterol.  His 10-year risk of cardiovascular events is calculated as 10%, and a discussion regarding moderate or intensive statin therapy is initiated.  The patient has read that statins may cause diabetes and asks if there is an even more increased risk with intensive compared to moderate statin therapy. Based on the abstract, what was the pooled odds ratio of major cardiovascular events among participants on intensive compared to moderate statin therapy?


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