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An 84-Year-Old Man Comes to the Physician with Persistent Dyspnea

question 1028

Multiple Choice

An 84-year-old man comes to the physician with persistent dyspnea despite being treated with optimal medical therapy for congestive heart failure with low left ventricular ejection fraction. A recently published randomized clinical trial compared an angiotensin-neprilysin inhibitor (ANi) to an angiotensin-converting enzyme inhibitor (ACEi) in patients who have heart failure with a reduced ejection fraction. The following results were reported: $An 84-year-old man comes to the physician with persistent dyspnea despite being treated with optimal medical therapy for congestive heart failure with low left ventricular ejection fraction. A recently published randomized clinical trial compared an angiotensin-neprilysin inhibitor (ANi) to an angiotensin-converting enzyme inhibitor (ACEi) in patients who have heart failure with a reduced ejection fraction. The following results were reported: The investigators also reported the following results for patients in the angiotensin-neprilysin inhibitor (ANi) and angiotensin-converting enzyme inhibitor (ACEi) groups: Which of the following is the best interpretation of these results A) The interpretation of the results is confounded by the placebo effect B) The study results reassure that there is no danger of drug-induced angioedema with the new drug due to the absence of airway compromise C) There is a higher number of angioedema events with the new drug, warranting a larger randomized clinical trial to investigate safety D) There is a higher number of angioedema events with the new drug, warranting postmarketing surveillance if the drug is approved E) There is a small but statistically significant increase in the rate of angioedema with the new drug$ The investigators also reported the following results for patients in the angiotensin-neprilysin inhibitor (ANi) and angiotensin-converting enzyme inhibitor (ACEi) groups:
$An 84-year-old man comes to the physician with persistent dyspnea despite being treated with optimal medical therapy for congestive heart failure with low left ventricular ejection fraction. A recently published randomized clinical trial compared an angiotensin-neprilysin inhibitor (ANi) to an angiotensin-converting enzyme inhibitor (ACEi) in patients who have heart failure with a reduced ejection fraction. The following results were reported: The investigators also reported the following results for patients in the angiotensin-neprilysin inhibitor (ANi) and angiotensin-converting enzyme inhibitor (ACEi) groups: Which of the following is the best interpretation of these results A) The interpretation of the results is confounded by the placebo effect B) The study results reassure that there is no danger of drug-induced angioedema with the new drug due to the absence of airway compromise C) There is a higher number of angioedema events with the new drug, warranting a larger randomized clinical trial to investigate safety D) There is a higher number of angioedema events with the new drug, warranting postmarketing surveillance if the drug is approved E) There is a small but statistically significant increase in the rate of angioedema with the new drug$ Which of the following is the best interpretation of these results

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