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An 84-Year-Old Man Comes to the Physician with Persistent Dyspnea

question 1086

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An 84-year-old man comes to the physician with persistent dyspnea despite being treated with optimal medical therapy for congestive heart failure with low left ventricular ejection fraction.  A recently published randomized clinical trial compared an angiotensin-neprilysin inhibitor (ANi) to an angiotensin-converting enzyme inhibitor (ACEi) in patients who have heart failure with a reduced ejection fraction.  The following results were reported:
An 84-year-old man comes to the physician with persistent dyspnea despite being treated with optimal medical therapy for congestive heart failure with low left ventricular ejection fraction.  A recently published randomized clinical trial compared an angiotensin-neprilysin inhibitor (ANi)  to an angiotensin-converting enzyme inhibitor (ACEi)  in patients who have heart failure with a reduced ejection fraction.  The following results were reported:   Which of the following would be of most concern when switching from an ACEi to an ANi? A) Dangerous hyperkalemia B) Increased hospitalizations for heart failure C) Uncomfortable cough D) Unsafe drop in blood pressure E) Worsening renal function Which of the following would be of most concern when switching from an ACEi to an ANi?


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