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A 42-Year-Old Man Comes to the Emergency Department Due to 4

question 1109

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A 42-year-old man comes to the emergency department due to 4 days of nausea, skin rash, progressive weakness, and decreased urine output.  For the past few months he has also had fatigue, tingling in his hands and feet, and occasional joint pains.  The patient has had no fever, chest pain, dysuria, hematuria, or diarrhea.  He has no chronic medical problems and takes no medication.  The patient does not use tobacco or alcohol but used injection drugs during his early 20s.  Temperature is 37.6 C (99.8 F) , blood pressure is 150/90 mm Hg, pulse is 92/min, and respirations are 16/min.  BMI is 24.8 kg/m2.  Mucous membranes are dry with no lesions.  Cardiopulmonary auscultation is normal.  The liver edge is palpable 2 cm below the right costal margin.  Bilateral ankle reflexes are absent.  He has mild, bilateral, lower-extremity pitting edema and a palpable, nonblanchable, purpuric rash on both legs.  There is no joint swelling or erythema.  Laboratory results are as follows:
A 42-year-old man comes to the emergency department due to 4 days of nausea, skin rash, progressive weakness, and decreased urine output.  For the past few months he has also had fatigue, tingling in his hands and feet, and occasional joint pains.  The patient has had no fever, chest pain, dysuria, hematuria, or diarrhea.  He has no chronic medical problems and takes no medication.  The patient does not use tobacco or alcohol but used injection drugs during his early 20s.  Temperature is 37.6 C (99.8 F) , blood pressure is 150/90 mm Hg, pulse is 92/min, and respirations are 16/min.  BMI is 24.8 kg/m<sup>2</sup>.  Mucous membranes are dry with no lesions.  Cardiopulmonary auscultation is normal.  The liver edge is palpable 2 cm below the right costal margin.  Bilateral ankle reflexes are absent.  He has mild, bilateral, lower-extremity pitting edema and a palpable, nonblanchable, purpuric rash on both legs.  There is no joint swelling or erythema.  Laboratory results are as follows:   The diagnosis is established and the patient's renal function stabilizes with initial therapy.  Which of the following is most appropriate for the long-term management of this patient? A) Antibiotic prophylaxis B) Antiviral treatment C) Close observation with supportive care D) Extended immunosuppressive therapy E) Liver-kidney transplantation The diagnosis is established and the patient's renal function stabilizes with initial therapy.  Which of the following is most appropriate for the long-term management of this patient?


Definitions:

R-Square

A statistical measure that represents the proportion of the variance for a dependent variable that's explained by an independent variable or variables in a regression model.

Regression Line

A statistical tool represented as a line on a graph that best fits the data points, showing the relationship between two variables.

Profits

The financial gain obtained when the revenues from business activities exceed the expenses, costs, and taxes associated with the operation.

Exponential Smoothing

A time series forecasting method for smoothing data points by assigning exponentially decreasing weights over time.

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